I agree so far with everyone here. I have a little ball python that was the same way. At this point he might be looking at you as a predator, you are about 300 times his size and being aproached by something that big is a bit scary to him. What i did to calm Coconut down is to use gloves to pick him up. He might bite you but the gloves will keep him from tasting you. I think he has bitten you so many times that he knows your taste and who you are and that you mean to hurt him (which your not). Try the gloves and keep handling him. When you hold him make sure you support his entire body so he feels secure in your hands. Keep it up he will turn around.