I would think the biggest problem would be the fact that freezer burn would affect the smell, and since snakes key in quite a bit on the smell of the prey, they might not associate the "freezer burnt" smell with "edible".
I've noticed that my BP's tend to be more enthusiastic about fresh killed rats over F/T. I know that anything frozen can pick up a bit of freezer smell, and based on their reaction, the "untainted" fresh smell gets their attention faster than the F/T smell.




