Male being larger than female?

Now I know that females generally get larger than males. Right now though we have a male that is approximately 2000 grams breeding with a female that is around 2600 grams. We would like to breed him to another female, but the female we have in mind is only 1500 grams. I was wondering if their is an issue with breeding a male to a female when the male is a good bit larger than the female like in this situation it is 500 grams difference? I don't want to scare the begeebees out of the female her first time breeding.

There's no issue.

Hope this helps.

-adam