Very active and bad temper

This is my first snake and I've had her for about 3 weeks. The last 3 days she's been overly active and in a very bad mood. The last 2 times I have held her she has or tried to bite me. Usually she's a great snake perks up when I walk in the room or when I'm holding her and running my fingers along her body she will push her head against my cheek. So this new behaviour is really odd for her.:(

What is her heat and humidity at? Sounds like she could be stressed out about something.

Three weeks is not a very long time. Give her a week or two of hands off time except for cleaning and feeding so she can acclimate to the new home. Make sure she is eating with you reliably before you start handling her. The over activity and defensive attitude means that something may not be quite right. Two of the first things I would look into are temperature and security. Make sure you are not keeping her too hot, and make sure she has a secure hiding spot. If she is a baby it's completely normal for them to be defensive and should calm down pretty quickly.

Being very active means it's more than likely a stress related issue.

Make sure your husbandry is on spot, do not over handle your animal and make sure you are feeding enough.

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Her tank has plenty of hiding places, her temp during the day is between 80-85 and at night it's in the 90's. The humidity is 55%. I just started handling her last week 3 x a week for short periods. The past two times she has bit or tried to bite me

Plenty of hiding places might not be enough depending on the size of the animal and the size of the enclosure sometime downsizing the enclosure size is a better option (can't tell without more details)

You want to have temps as stable as possible with a young animal 76/78 on the cool side and 86/88 on the warm side offer a great temp gradient.