Question about BP making noises

So I opened the enclosure last night and grabbed my python as normally do to handle her at night. I didn't notice with the red night light on and walked to to a lit room and noticed her eyes were pale white from going into shed. Happy about that cause I was worrying about it for about a week +. While I was holding her though she made like a high pitched wheeze/whistle sound only once. I've read that can be a sign of a RI but should I be concerned if it was just once out of the whole 10 minutes I held her? Or am I just being overly paranoid?

It is very common during a shed to hear different noises when they breath.

It could have been a hiss. My girl hissed at me once when I took her out and I didn't know she was in shed. Sounded like air coming out of a tire. I think it's a defensive thing since they can't really see with their eyes like that.

They do wheeze when they are going into shed, nothing to worry about :)