Just a few questions to make sure I'm doing it right

[LestertheLesser]

Well I have two ball pythons. A normal female and a lesser male. They're both beautiful and healthy. My lesser is 1000 grams, and my female is much smaller. My female is a normal and was born 1/2014 And she's very small. Is this okay? She's in a big bow front, 46 gallons to be exact. She doesn't do well in a smaller enclosure and seems to like a way too big of an enclosure for her. If I had to guess she's only 400-500 grams. Hot side is 90, cool side is 84 (ambient) and humidity is about 60% at all times. She eats a medium rat once a week but is still pretty small. Am I okay or should I change something? My male lesser I got about a few weeks ago. He came to me with a respiratory infection and after hundreds of dollars at the vet he seems to be turning around. I feed him a large rat once a week and in only two weeks he gained over 200 grams! He's in a 75 gallon and seems to be loving it. Both tanks are full heated, both top and bottom, and is controlled by sensors. I use a digital point and shoot thermometer to get there temperatures too, to double check. Is there anything I should change? I read that the enclosures are too big but when I move them to a smaller enclosure they don't eat and act funny but are fine in there insanely large enclosures. I work a lot so no ones home during the day and I take them out every night for a few minutes.

Spark notes:

Are my enclosures too large even though the snakes enough them?

Is once a day too much handling if they show no signs of stress of anything like that. They both "seem" to like being handled often.

Is it weird if my snakes come out right when I get home. I notice when I walk in both of them sliver out with in a few minutes and just look at me. (Both are well fed). A

[DVirginiana]

Those enclosures do kind of sound too big, but if the snakes are eating, drinking, and spend the majority of their time hiding (constantly being out and 'pacing' the tank is a sign of stress) I wouldn't worry about it as long as you can keep the temp/humidity right.

If they are acting stressed, try a smaller enclosure. Adding in lots of fake plants to cover the floor also seems to help. How long were they acting funny in the smaller enclosures? It can take several weeks for BPs to get used to any new environment. But like I said, if they aren't acting stressed, you probably don't need to switch the enclosures.

A short amount of handling daily is fine. I like to handle at least every day/every other day (just not right after feeding) in order to check my snakes' health and catch any problems early on. If the snakes start acting stressed or refusing food, it's good to cut back on handling though.

Coming out when you enter the room is fairly normal. Even though they're well fed, they don't realize another rodent will magically appear in a few days so they're still looking for food.