It's already been stated that this system will work with mice, you just have to adjust the rotation times and keep in mind that mice have a shorter period where they can viably (not to mention safely!) breed. I've personally kept a very small colony of mice before so the only thing I want to add is this; be careful reintroducing the female mice to the male during rotation. Mice are highly territorial and do not react well to newcomers entering a cage that smells like them (the resident mouse). I always suggest fully cleaning the tank/cage and rearranging all the objects kept in the tank afterwards when introducing mice to the same tank/cage (yes, even if they have met before!). I had one female that would pick a fight with her sisters every time I reintroduced them, even though she had been raised with them.