This time of year, with the weather changing so dramatically every day, I end up going around checking temps daily. Since I use a tempgun, I do have to lift each of the snakes for a period of time. I do try to get them out for some serious handling once or twice a week, more often with the blood because he gets real nippy if he doesn't get handled regularly.
I love holding them and admiring them, but I honestly don't have the time. Besides, I'm always bound to have one or two in shed, and they need a few days a week to digest + a day before feeding to relax.